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Congeners of the .beta. conformer of dopamine derived from cis- and trans-octahydrobenzo[f]quinoline and trans-octahydrobenzo[g]quinoline Joseph G. Cannon, Teresa Lee, H. Duane Goldman, John Paul Long, Jan R. Flynn, Turkiz Verimer, Brenda Costall, and Robert J. Naylor pp 1 - 5; DOI: 10.1021/jm00175a001 |
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Use of acetylacetone to prepare a prodrug of cycloserine N. P. Jensen, J. J. Friedman, H. Kropp, and F. M. Kahan pp 6 - 8; DOI: 10.1021/jm00175a002 |
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Glycerides as prodrugs. 3. Synthesis and antiinflammatory activity of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetyl]glycerides (indomethacin glycerides) Gerard Y. Paris, David L. Garmaise, Denis G. Cimon, Leo Swett, George W. Carter, and Patrick Young pp 9 - 13; DOI: 10.1021/jm00175a003 |
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Basic antiinflammatory compounds. N,N',N''-Trisubstituted guanidines Schneur Rachlin, E. Bramm, I. Ahnfelt-Roenne, and E. Arrigoni-Martelli pp 13 - 20; DOI: 10.1021/jm00175a004 |
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Adaptive least-squares method applied to structure-activity correlation of hypotensive N-alkyl-N''-cyano-N'-pyridylguanidines Ikuo Moriguchi, Katsuichiro Komatsu, and Yasuo Matsushita pp 20 - 26; DOI: 10.1021/jm00175a005 |
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Synthesis of analogs of the carboxyl protease inhibitor pepstatin. Effect of structure on inhibition of pepsin and renin Daniel H. Rich, Eric T. O. Sun, and Edgar Ulm pp 27 - 33; DOI: 10.1021/jm00175a006 |
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Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils George E. Wright and Neal C. Brown pp 34 - 38; DOI: 10.1021/jm00175a007 |
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Binding specificities of adenosine aminohydrolase from calf intestinal mucosa with dialdehydes derived from hexofuranosyladenine nucleosides Alan J. Grant and Leon M. Lerner pp 39 - 42; DOI: 10.1021/jm00175a008 |
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Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B Virendra Kumar, Gerald S. Jones, Ilene Blacksberg, William A. Remers, Martin Misiek, and Theresa A. Pursiano pp 42 - 49; DOI: 10.1021/jm00175a009 |
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Studies of hypolipidemic agents. 1. Synthesis and hypolipidemic activities of alkoxycinnamic acid derivatives Toshio Watanabe, Kimiaki Hayashi, Shigeki Yoshimatsu, Kazuo Sakai, Shigeyuki Takeyama, and Kohki Takashima pp 50 - 59; DOI: 10.1021/jm00175a010 |
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Folate analogs altered in the C9-N10 bridge region. 14. 11-Oxahomofolic acid, a potential antitumor agent M. G. Nair, Colleen Saunders, Shiang-Yuan Chen, Roy L. Kisliuk, and Y. Gaumont pp 59 - 65; DOI: 10.1021/jm00175a011 |
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Heterocyclic analogs of the antihypertensive .beta.-adrenergic blocking agent (S)-2-[3-(tert-butylamino)-2-hydroxypropoxy]-3-cyanopyridine John J. Baldwin, Edward L. Engelhardt, Ralph Hirschmann, Gerald S. Ponticello, Joseph G. Atkinson, Burton K. Wasson, Charles S. Sweet, and Alexander Scriabine pp 65 - 70; DOI: 10.1021/jm00175a012 |
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Synthesis and pharmacology of 8-amino-3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-cis-6,11-dimethyl-2,6-methano-3-benzazocine and related compounds Mark P. Wentland, Noel F. Albertson, and Anne K. Pierson pp 71 - 74; DOI: 10.1021/jm00175a013 |
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Synthesis of [82Br]bromperidol and preliminary tissue distribution studies in the rat Styliani H. Vincent, Manvendra B. Shambhu, and George A. Digenis pp 75 - 79; DOI: 10.1021/jm00175a014 |
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Glycerides as prodrugs. 2. 1,3-Dialkanoyl-2-(2-methyl-4-oxo-1,3-benzodioxan-2-yl)glycerides (cyclic aspirin triglycerides) as antiinflammatory agents Gerard Y. Paris, David L. Garmaise, Denis G. Cimon, Leo Swett, George W. Carter, and Patrick Young pp 79 - 82; DOI: 10.1021/jm00175a015 |
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Cholecystokinin (pancreozymin). 5. Hormonally active desamino derivative of Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 Miklos Bodanszky, Jean Martinez, Michael Walker, Jerry D. Gardner, and Viktor Mutt pp 82 - 85; DOI: 10.1021/jm00175a016 |
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Potential carcinostatics. 4. Synthesis and biological properties of erythro- and threo-.beta.-fluoroaspartic acid and erythro-.beta.-fluoroasparagine Martinus J. Wanner, Johanna J. M. Hageman, Gerrit Jan Koomen, and Upendra K. Pandit pp 85 - 87; DOI: 10.1021/jm00175a017 |
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Vinylogous carbinolamine tumor inhibitors. 6. Synthesis and antileukemic activity of 1-methyl-2,5-diphenyl-3,4-bis(hydroxymethyl)-, 1,2,3-triphenyl-4,5-bis(hydroxymethyl)-, and 1-methyl-2,3-diphenyl-4,5-bis(hydroxymethyl)pyrrole bis(N-methylcarbamate) Wayne K. Anderson, Michael J. Halat, and Arvela C. Rick pp 87 - 89; DOI: 10.1021/jm00175a018 |
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Steroidal .alpha.-methylene .delta.-lactones as potential antitumor agents Shangara S. Dehal, Brian A. Marples, Reginald J. Stretton, and John R. Traynor pp 90 - 92; DOI: 10.1021/jm00175a019 |
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Pyrido[2,1-b]quinazolinecarboxylic acids as orally active antiallergy agents Jefferson W. Tilley, Ronald A. LeMahieu, Mathew Carson, Richard W. Kierstead, Herman W. Baruth, and Bohdan Yaremko pp 92 - 95; DOI: 10.1021/jm00175a020 |
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Synthesis of 8-methoxy-15,16-dinor-6,8,10-trichothecatriene 12,13.alpha.-epoxide and 12,13.beta.-epoxide as potential antineoplastic agents Wayne K. Anderson and George E. Lee pp 96 - 97; DOI: 10.1021/jm00175a021 |
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Synthesis and biological activity of 5-(4-chlorobenzoyl)-4-(hydroxymethyl)-1-methyl-1H-pyrrole-2-acetic acid, a major metabolite of zomepirac sodium Neal G. Anderson and John R. Carson pp 98 - 100; DOI: 10.1021/jm00175a022 |
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Book Reviews pp 100 - 102; DOI: 10.1021/jm00175a600 |
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Perspectives on the design and biochemical pharmacology of inhibitors of thymidylate synthetase Daniel V. Santi pp 103 - 111; DOI: 10.1021/jm00176a001 |
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.beta.-Adrenergic blocking agents. 19. 1-Phenyl-2-[[(substituted-amido)alkyl]amino]ethanols M. S. Large and L. H. Smith pp 112 - 117; DOI: 10.1021/jm00176a002 |
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Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 2. Imidazo[2,1-b]thiadiazole and imidazo[2,1-b]thiazolesulfonamides Ian T. Barnish, Peter E. Cross, Roger P. Dickinson, Brian Gadsby, Michael J. Parry, Michael J. Randall, and Ian W. Sinclair pp 117 - 121; DOI: 10.1021/jm00176a003 |
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Inhibitors of polyamine biosynthesis. 8. Irreversible inhibition of mammalian S-adenosyl-L-methionine decarboxylase by substrate analogs Marvin Pankaskie and Mahmoud M. Abdel-Monem pp 121 - 127; DOI: 10.1021/jm00176a004 |
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Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogs George T. Shiau, Raymond F. Schinazi, Ming S. Chen, and William H. Prusoff pp 127 - 133; DOI: 10.1021/jm00176a005 |
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Trapping of metabolically generated electrophilic species with cyanide ion: metabolism of 1-benzylpyrrolidine Bert Ho and Neal Castagnoli pp 133 - 139; DOI: 10.1021/jm00176a006 |
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Structural requirements for the sequestration of metabolically generated acetaldehyde Herbert T. Nagasawa, James A. Elberling, and Eugene G. DeMaster pp 140 - 143; DOI: 10.1021/jm00176a007 |
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Halogenated L-fucose and D-galactose analogs: synthesis and metabolic effects Janice R. Sufrin, Ralph J. Bernacki, Michael J. Morin, and Walter Korytnyk pp 143 - 149; DOI: 10.1021/jm00176a008 |
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Synthesis and psychoanaleptic properties of new compounds structurally related to diphenhydramine Andre Buzas, Andre Champagnac, Andre Dehnel, Gilbert Lavielle, and Michele Pommier pp 149 - 153; DOI: 10.1021/jm00176a009 |
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Phenylalkylamines with potential psychotherapeutic utility. 2. Nuclear substituted 2-amino-1-phenylbutanes Robert T. Standridge, Henry G. Howell, Hugh A. Tilson, John H. Chamberlain, Henry M. Holava, Jonas A. Gylys, Richard A. Partyka, and Alexander T. Shulgin pp 154 - 162; DOI: 10.1021/jm00176a010 |
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Synthesis and analgesic activity of some 14.beta.-substituted analogs of morphine Peter Osei-Gyimah and Sydney Archer pp 162 - 166; DOI: 10.1021/jm00176a011 |
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Analgesic narcotic antagonists. 1. 8.beta.-Alkyl-, 8.beta.-acyl-, and 8.beta.-(tertiary alcohol)dihydrocodeinones and -dihydromorphinones Michael P. Kotick, David L. Leland, Joseph O. Polazzi, and Robert N. Schut pp 166 - 174; DOI: 10.1021/jm00176a012 |
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Analgesic narcotic antagonists. 2. 8-Alkylmorphinan-6-ones Joseph O. Polazzi, Robert N. Schut, Michael P. Kotick, John F. Howes, Patricia F. Osgood, Raj K. Razdan, and Julian E. Villarreal pp 174 - 179; DOI: 10.1021/jm00176a013 |
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Mono- and diaryl-2-quinuclidinylcarbinols with local anesthetic and antiarrhythmic activity P. H. Nelson, A. M. Strosberg, and K. G. Untch pp 180 - 184; DOI: 10.1021/jm00176a014 |
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Quantitative structure-activity relationships for N-[(N',N'-disubstituted-amino)acetyl]arylamines for local anesthetic activity and acute toxicity Francoise Heymans, Laurence Le Therizien, Jean Jacques Godfroid, and Pierre Bessin pp 184 - 193; DOI: 10.1021/jm00176a015 |
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Rm values and structure-activity relationship of benzodiazepines G. L. Biagi, A. M. Barbaro, M. C. Guerra, M. Babbini, M. Gaiardi, M. Bartoletti, and P. A. Borea pp 193 - 201; DOI: 10.1021/jm00176a016 |
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Antiamebic amidines and sulfonamides of 5- and 6-amino-2,3-bis(4-alkyl-1-piperazazinyl)quinoxalines Paul F. Fabio, S. A. Lang, Yang-I Lin, and Andrew S. Tomcufcik pp 201 - 206; DOI: 10.1021/jm00176a017 |
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Synthesis and antiarrhythmic properties of some 5-benzamido-2-methyl-trans-decahydroisoquinolines Ian W. Mathison and Robert J. Pennington pp 206 - 209; DOI: 10.1021/jm00176a018 |
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Synthesis and biological activity of flavipucine analogs N. N. Girotra, A. A. Patchett, S. B. Zimmerman, D. L. Achimov, and N. L. Wendler pp 209 - 213; DOI: 10.1021/jm00176a019 |
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Oxytocin and lysine-vasopressin with N5,N5-dialkylglutamine in the 4 position: effect of introducing sterically hindered groups into the hydrophilic cluster of neurohypophyseal hormones Glenn L. Stahl, Clark W. Smith, Roderich Walter, Theodor Tsegenidis, George Stavropoulos, Paul Cordopatis, and Dimitrios Theodoropoulos pp 213 - 217; DOI: 10.1021/jm00176a020 |
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[5-(N4,N4-Dimethylasparagine),8-lysine]vasopressin: the first 5-position neurohypophyseal hormone analog to retain significant antidiuretic potency Clark W. Smith, Roderich Walter, George Stavropoulos, and Dimitrios Theodoropoulos pp 217 - 219; DOI: 10.1021/jm00176a021 |
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Cannabidiol and phenytoin: a structural comparison Ilana Tamir, Raphael Mechoulam, and Amatzya Y. Meyer pp 220 - 223; DOI: 10.1021/jm00176a022 |
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Book Reviews pp 223 - 224; DOI: 10.1021/jm00176a600 |
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Reminiscences and musings of a classical medicinal chemist Everette L. May pp 225 - 232; DOI: 10.1021/jm00177a001 |
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A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities Philip S. Portoghese, Dennis L. Larson, Lawrence M. Sayre, David S. Fries, and A. E. Takemori pp 233 - 234; DOI: 10.1021/jm00177a002 |
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10,10-Difluoro-13-dehydroprostacyclin: a chemically and metabolically stabilized potent prostacyclin Josef Fried, D. K. Mitra, M. Nagarajan, and M. M. Mehrotra pp 234 - 237; DOI: 10.1021/jm00177a003 |
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5-Substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents Wendell Wierenga, Harvey I. Skulnick, Dale A. Stringfellow, Sheldon D. Weed, Harold E. Renis, and Emerson E. Eidson pp 237 - 239; DOI: 10.1021/jm00177a004 |
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Biomimetic synthesis of catechol estrogens: potentially mutagenic arene oxide intermediates in estrogen metabolism Philip W. Le Quesne, Adhyam V. Durga, Vinayakam Subramanyam, Albert H. Soloway, Ronald W. Hart, and Robert H. Purdy pp 239 - 240; DOI: 10.1021/jm00177a005 |
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Synthetic modulators of the complement system. 1. Synthesis and biological activity of 5,5',5"-[1,3,6-naphthalenetriyltris(sulfonylimino)]tris[1,3-benzenedisulfonate] hexasodium salt R. B. Conrow, N. Bauman, J. A. Brockman, and S. Bernstein pp 240 - 242; DOI: 10.1021/jm00177a006 |
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Synthesis and enzymic and ionotropic activity of some new 8-substituted and 6,8-disubstituted derivatives of adenosine cyclic 3',5'-monophosphate Jon P. Miller, Kay H. Boswell, Rich B. Meyer, Leon F. Christensen, and Roland K. Robins pp 242 - 251; DOI: 10.1021/jm00177a007 |
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Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition Charles L. Schmidt, Charles T. C. Chang, Erik De Clercq, Johan Descamps, and Mathias P. Mertes pp 252 - 256; DOI: 10.1021/jm00177a008 |
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Quantitative structure-activity correlations of rifamycins as inhibitors of viral RNA-directed DNA polymerase and mammalian .alpha. and .beta. DNA polymerases Roy S. Wu, Mary K. Wolpert DeFilippes, and Frank R. Quinn pp 256 - 261; DOI: 10.1021/jm00177a009 |
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Structure-activity relationships in a series of novel 3,4-dihydro-4-oxopyrimido[4,5-b]quinoline-2-carboxylic acid antiallergy agents T. H. Althuis, S. B. Kadin, L. J. Czuba, P. F. Moore, and H. J. Hess pp 262 - 269; DOI: 10.1021/jm00177a010 |
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Potential antitumor agents. 33. Quantitative structure-activity relationships for mutagenic activity and antitumor activity of substituted 4'-(9-acridinylamino)methanesulfonanilide derivatives Lynnette R. Ferguson and William A. Denny pp 269 - 274; DOI: 10.1021/jm00177a011 |
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Antitumor agents: diazomethyl ketone and chloromethyl ketone analogs prepared from N-tosyl amino acids Z. Sajadi, M. Kashani, L. J. Loeffler, and I. H. Hall pp 275 - 278; DOI: 10.1021/jm00177a012 |
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Synthesis and mutagenicity of A-ring reduced analogs of 7,12-dimethylbenz[a]anthracene Muthiah N. Inbasekaran, Donald T. Witiak, Karen Barone, and John C. Loper pp 278 - 281; DOI: 10.1021/jm00177a013 |
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Synthesis and study of conformationally defined enantiomers of local anesthetics and conformationally defined enantiomers of fluorescent dyes designed to label electrically excitable membranes Henry G. Mautner, Carol Lorenc, Paul Quain, Judith K. Marquis, and Ichiji Tasaki pp 282 - 285; DOI: 10.1021/jm00177a014 |
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Antihypertensive indole derivatives of phenoxypropanolamines with .beta.-adrenergic receptor antagonist and vasodilating activity William E. Kreighbaum, W. Lesley Matier, Ronald D. Dennis, Joseph L. Minielli, David Deitchman, James L. Perhach, and William T. Comer pp 285 - 289; DOI: 10.1021/jm00177a015 |
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Synthesis, in vitro opiate activity, and intramolecular tyrosine-tryptophan distances of (4-tryptophan)enkephalin analogs. A reassessment of conformational models of enkephalin in solution Peter W. Schiller and Johanne St.-Hilaire pp 290 - 294; DOI: 10.1021/jm00177a016 |
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Serotonin receptor affinities of psychoactive phenalkylamine analogs Richard A. Glennon, Stephen M. Liebowitz, and George M. Anderson pp 294 - 299; DOI: 10.1021/jm00177a017 |
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Cyclophosphamide potentiation and aldehyde oxidase inhibition by phosphorylated aldehydes and acetals Lindley A. Cates, Gerald S. Jones, Daniel J. Good, Helen Y. L. Tsai, Ven-Shun Li, Norman Caron, Shiao-Chun Tu, and Aubrey P. Kimball pp 300 - 304; DOI: 10.1021/jm00177a018 |
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Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen Mark W. Gemborys, Gilbert H. Mudge, and Gordon W. Gribble pp 304 - 308; DOI: 10.1021/jm00177a019 |
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Structure-taste relationship of perillartine and nitro- and cyanoaniline derivatives Hajime Iwamura pp 308 - 312; DOI: 10.1021/jm00177a020 |
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Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides Raj Nandan Prasad, Dilbagh S. Bariana, Anthony Fung, Milica Savic, Karin Tietje, Herman H. Stein, Harold Brondyk, and Richard S. Egan pp 313 - 319; DOI: 10.1021/jm00177a021 |
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Convenient synthesis of 10-deazaaminopterin via a pteridine ylide James R. Piper and John A. Montgomery pp 320 - 321; DOI: 10.1021/jm00177a022 |
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Synthesis of isomeric thienobenzothiazines and their effect on dopamine metabolism in rat brain Cor J. Grol, Hans Rollema, Durk Dijkstra, and Ben H. C. Westerink pp 322 - 324; DOI: 10.1021/jm00177a023 |
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Synthesis and anticancer activity of nitrosourea derivatives of phensuximide A. Michael Crider, Thomas M. Kolczynski, and Kathleen M. Yates pp 324 - 326; DOI: 10.1021/jm00177a024 |
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Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine Eugene M. Grivsky, Shuliang Lee, Carl W. Sigel, David S. Duch, and Charles A. Nichol pp 327 - 329; DOI: 10.1021/jm00177a025 |
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Synthesis and biological activity of some 15-oxaestranes Perry Rosen, Alfred Boris, and Gloria Oliva pp 329 - 330; DOI: 10.1021/jm00177a026 |
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Synthesis, .beta.-adrenergic activity, and platelet antiaggregatory activity of a positional isomer of trimetoquinol: 1-(2',4',5'-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline Duane D. Miller, Josef F. Bossart, Joseph R. Mayo, and Dennis R. Feller pp 331 - 333; DOI: 10.1021/jm00177a027 |
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Central nervous system activity of 7-substituted 1-azaphenoxathiin analogs and their oxidation products Arthur J. Elliott, Norman Eisenstein, and Louis C. Iorio pp 333 - 335; DOI: 10.1021/jm00177a028 |
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Inhibition of histamine-induced gastric secretion by flavone-6-carboxylic acids Juerg R. Pfister, Walter E. Wymann, Margery E. Schuler, and Adolph P. Roszkowski pp 335 - 338; DOI: 10.1021/jm00177a029 |
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Conformational energy differences between side chain alkylated analogs of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane Herschel J. R. Weintraub, David E. Nichols, Alexandros Makriyannis, and Stephen W. Fesik pp 339 - 341; DOI: 10.1021/jm00177a030 |
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Book Reviews pp 342 - 346; DOI: 10.1021/jm00177a600 |
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S-Adenosyl-L-methionine-dependent macromolecule methyltransferases: potential targets for the design of chemotherapeutic agents Ronald T. Borchardt pp 347 - 357; DOI: 10.1021/jm00178a001 |
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Synthesis of potential inhibitors of hypoxanthine-guanine phosphoribosyltransferase for testing as antiprotozoal agents. 1. 7-Substituted 6-oxopurines James R. Piper, Anne G. Laseter, and John A. Montgomery pp 357 - 364; DOI: 10.1021/jm00178a002 |
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[1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid),2-(O-methyl)tyrosine]arginine-vasopressin and [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)]arginine-vasopressin, two highly potent antagonists of the vasopressor response to arginine-vasopressin Marian Kruszynski, Bernard Lammek, Maurice Manning, Janny Seto, Jaya Haldar, and Wilbur H. Sawyer pp 364 - 368; DOI: 10.1021/jm00178a003 |
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Synthesis of syn and anti isomers of 6-[[(hydroxyimino)phenyl]methyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine. Inhibitors of rhinovirus multiplication J. H. Wikel, C. J. Paget, D. C. DeLong, J. D. Nelson, C. Y. E. Wu, J. W. Paschal, A. Dinner, R. J. Templeton, M. O. Chaney, and et al. pp 368 - 372; DOI: 10.1021/jm00178a004 |
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Synthesis and antitumor activity of cyclophosphamide analogs. 3. Preparation, molecular structure determination, and anticancer screening of racemic cis- and trans-4-phenylcyclophosphamide Victoria L. Boyd, Gerald Zon, Vicky L. Himes, Judith K. Stalick, Alan D. Mighell, and Henry V. Secor pp 372 - 375; DOI: 10.1021/jm00178a005 |
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Preparation and antitumor activity of olivomycin A analogs Virendra Kumar, William A. Remers, and William T. Bradner pp 376 - 379; DOI: 10.1021/jm00178a006 |
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2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 2. C-Alkylation of pyrimidines with Mannich bases and application to the synthesis of trimethoprim and analogs Barbara Roth, Justina Z. Strelitz, and Barbara S. Rauckman pp 379 - 384; DOI: 10.1021/jm00178a007 |
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2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 3. C-Benzylation of aminopyridines with phenolic Mannich bases. Synthesis of 1- and 3-deaza analogs of trimethoprim Barbara S. Rauckman and Barbara Roth pp 384 - 391; DOI: 10.1021/jm00178a008 |
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1-(Aminoalkyl)-6-aryl-4H-s-triazolo[4,3-a][1,4]benzodiazepines with antianxiety and antidepressant activity Jackson B. Hester, Allan D. Rudzik, and Philip F. Von Voigtlander pp 392 - 402; DOI: 10.1021/jm00178a009 |
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2,4-Dihydro-6-phenyl-1H-s-triazolo[4,3-a][1,4]benzodiazepin-1-ones with antianxiety and antidepressant activity Jackson B. Hester, Allan D. Rudzik, and Philip Von Voigtlander pp 402 - 405; DOI: 10.1021/jm00178a010 |
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Orally active cephalosporins and penicillins E. H. W. Boehme, R. E. Bambury, R. J. Baumann, R. C. Erickson, B. L. Harrison, P. F. Hoffman, F. J. McCarty, R. A. Schnettler, M. J. Vaal, and D. L. Wenstrup pp 405 - 412; DOI: 10.1021/jm00178a011 |
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Peptide sweeteners. 3. Effect of modifying the peptide bond on the sweet taste of L-aspartyl-L-phenylalanine methyl ester and its analogs Scott A. MacDonald, C. Grant Willson, Michael Chorev, Fred S. Vernacchia, and Murray Goodman pp 413 - 420; DOI: 10.1021/jm00178a012 |
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Peptide sweeteners. 4. Hydroxy and methoxy substitution of the aromatic ring in L-aspartyl-L-phenylalanine methyl ester. Structure-taste relationships Masao Kawai, Michael Chorev, Janine Marin-Rose, and Murray Goodman pp 420 - 424; DOI: 10.1021/jm00178a013 |
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4-Amino-4-arylcyclohexanones and their derivatives, a novel class of analgesics. 1. Modification of the aryl ring Daniel Lednicer, Philip F. Von Voigtlander, and D. Edward Emmert pp 424 - 430; DOI: 10.1021/jm00178a014 |
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Synthesis and structure-activity studies in a series of 7.alpha.-halogeno corticosteroids Ho-Jane Shue, Michael J. Green, Joseph Berkenkoph, Margaret Monahan, Xiomara Fernandez, and Barry N. Lutsky pp 430 - 437; DOI: 10.1021/jm00178a015 |
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Structure-activity study of antiulcerous and antiinflammatory drugs by discriminant analysis Akio Ogino, Shingo Matsumura, and Toshio Fujita pp 437 - 444; DOI: 10.1021/jm00178a016 |
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Convulsant and anticonvulsant barbiturates. 1. Molecular conformations from classical potential-energy calculations G. P. Jones and P. R. Andrews pp 444 - 448; DOI: 10.1021/jm00178a017 |
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Decomposition of pharmacological activity indices into mutually independent components using principal component analysis Istvan Lukovits and Antal Lopata pp 449 - 459; DOI: 10.1021/jm00178a018 |
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Mutagenicity of substituted (o-phenylenediamine)platinum dichloride in the Ames test. A quantitative structure-activity analysis Corwin Hansch, Benjamin H. Venger, and Augustine Panthananickal pp 459 - 461; DOI: 10.1021/jm00178a019 |
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Derivatives of 11-(1-piperazinyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine as central nervous system agents William B. Wright, Eugene N. Greenblatt, Ivana P. Day, Nicanor Q. Quinones, and Robert A. Hardy pp 462 - 465; DOI: 10.1021/jm00178a020 |
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Book Reviews pp 466 - 468; DOI: 10.1021/jm00178a600 |
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Soft drugs. 1. Labile quaternary ammonium salts as soft antimicrobials Nicholas Bodor, James J. Kaminski, and Sally Selk pp 469 - 474; DOI: 10.1021/jm00179a001 |
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Soft drugs. 3. A new class of anticholinergic agents Nicholas Bodor, Ross Woods, Colin Raper, Pauline Kearney, and James J. Kaminski pp 474 - 480; DOI: 10.1021/jm00179a002 |
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Bicyclic and tricyclic ergoline partial structures. Rigid 3-(2-aminoethyl)pyrroles and 3- and 4-(2-aminoethyl)pyrazoles as dopamine agonists Nicholas J. Bach, Edmund C. Kornfeld, Noel D. Jones, Michael O. Chaney, Douglas E. Dorman, Jonathan W. Paschal, James A. Clemens, and E. Barry Smalstig pp 481 - 491; DOI: 10.1021/jm00179a003 |
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Preparation and biological evaluation of 2-azaergolines Nicholas J. Bach, Edmund C. Kornfeld, James A. Clemens, E. Barry Smalstig, and Robert C. A. Frederickson pp 492 - 494; DOI: 10.1021/jm00179a004 |
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Tricyclics with analgesic and antidepressant activity. 1. [[(Alkylamino)ethyl]thio]dibenz[b,f]oxepins and 10,11-dihydro derivatives Helen H. Ong, James A. Profitt, V. Brian Anderson, Theodore C. Spaulding, Jeffrey C. Wilker, Harry M. Geyer, and Hansjoerg Kruse pp 494 - 501; DOI: 10.1021/jm00179a005 |
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Congeners of the .alpha. conformer of dopamine derived from octahydrobenz[h]isoquinoline Joseph G. Cannon, Teresa Lee, Fu-Lian Hsu, John Paul Long, and Jan R. Flynn pp 502 - 505; DOI: 10.1021/jm00179a006 |
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Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 1. Chloro-Substituted 1,2,3,4-tetrahydroisoquinolines William E. Bondinell, Frederic W. Chapin, Gerald R. Girard, Carl Kaiser, Arnold J. Krog, Alex M. Pavloff, Mark S. Schwartz, Joanne S. Silvestri, Praful D. Vaidya, and et al. pp 506 - 511; DOI: 10.1021/jm00179a007 |
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New cyclopenta[a]naphthalene derivatives. Synthesis of 2-(carbamylmethyl)-8-hydroxy-3H-cyclopenta[a]naphthalene as a possible deoxyribonucleic acid binding agent Nitya G. Kundu pp 512 - 516; DOI: 10.1021/jm00179a008 |
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4-[(Aminoalkyl)amino]-1,2-dimethoxynaphthalenes as antimalarial agents Sydney Archer, Peter Osei-Gyimah, and Stephen Silbering pp 516 - 519; DOI: 10.1021/jm00179a009 |
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Prostaglandin analogs possessing antinidatory effects. 1. Modification of the .omega. chain Masaki Hayashi, Hajimu Miyake, Seiji Kori, Tadao Tanouchi, Hirohisa Wakatsuka, Yoshinobu Arai, Takashi Yamato, Ikuo Kajiwara, Yoshitaka Konishi, and et al. pp 519 - 524; DOI: 10.1021/jm00179a010 |
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Prostaglandin analogs possessing antinidatory effects. 2. Modification of the .alpha. chain Masaki Hayashi, Yoshinobu Arai, Hirohisa Wakatsuka, Masanori Kawamura, Yoshitaka Konishi, Takeshi Tsuda, and Kimiichiro Matsumoto pp 525 - 535; DOI: 10.1021/jm00179a011 |
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2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 4. 6-Substituted trimethoprim derivatives from phenolic Mannich intermediates. Application to the synthesis of trimethoprim and 3,5-dialkylbenzyl analogs Barbara Roth, Edward Aig, Kenneth Lane, and Barbara S. Rauckman pp 535 - 541; DOI: 10.1021/jm00179a012 |
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Synthesis, biological activity, and structure-activity/toxicity relationships of a series of terphenyl analogs of hemicholinium-3 and acetyl-seco-hemicholinium-3. 3 Floyd R. Domer, David M. Chihal, H. Cecil Charles, and Richard C. Koch pp 541 - 545; DOI: 10.1021/jm00179a013 |
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Structure-antitubulin activity relationships in steganacin congeners and analogs. Inhibition of tubulin polymerization in vitro by (.+-.)-isodeoxypodophyllotoxin Flora Zavala, Daniel Guenard, Jean Pierre Robin, and Eric Brown pp 546 - 549; DOI: 10.1021/jm00179a014 |
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Synthesis and antitumor activity of analogs of the antitumor antibiotic chartreusin Makoto Takai, Yoshimasa Uehara, and John A. Beisler pp 549 - 553; DOI: 10.1021/jm00179a015 |
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Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogs Mansukh C. Wani, Peter E. Ronman, James T. Lindley, and Monroe E. Wall pp 554 - 560; DOI: 10.1021/jm00179a016 |
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Accumulation of drugs by guinea pig isolated atria. Quantitative correlations Heinz Luellmann, Pieter B. M. W. M. Timmermans, Gerhard M. Weikert, and Albrecht Ziegler pp 560 - 565; DOI: 10.1021/jm00179a017 |
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Soft drugs. 2. Soft alkylating compounds as potential antitumor agents Nicholas Bodor and James J. Kaminski pp 566 - 569; DOI: 10.1021/jm00179a018 |
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Synthesis of some new S-alkylated derivatives of 5-mercapto-2'-deoxyuridine as potential antiviral agents Frank J. Dinan and Thomas J. Bardos pp 569 - 572; DOI: 10.1021/jm00179a019 |
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A direct method for the preparation of 2-hydroxyethoxymethyl derivatives of guanine, adenine, and cytosine Jorge R. Barrio, Jerry D. Bryant, and Gene E. Keyser pp 572 - 574; DOI: 10.1021/jm00179a020 |
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Synthesis and properties of the sulfonyl analogs of 4(5)-aminoimidazole-5(4)-carboxamide, 4(5)-(formylamino)imidazole-5(4)-carboxamide, guanine, and xanthine Bao-Shan Huang, Paul L. Chello, Lily Yip, and James C. Parham pp 575 - 577; DOI: 10.1021/jm00179a021 |
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Synthesis and antitrypanosomal activity of some bis(4-guanylphenyl) five- and six-membered ring heterocycles Bijan P. Das, Rebecca A. Wallace, and David Withers Boykin pp 578 - 581; DOI: 10.1021/jm00179a022 |
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Synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogs as potential antiparasitics F. Ivy Carroll, Bertold D. Berrang, and C. Preston Linn pp 581 - 584; DOI: 10.1021/jm00179a023 |
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Role of iodine in thyroid hormones: molecular conformation of a halogen-free hormone analog Vivian Cody pp 584 - 587; DOI: 10.1021/jm00179a024 |
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Book Reviews pp 587 - 590; DOI: 10.1021/jm00179a600 |
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Biological significance and therapeutic potential of prostacyclin S. Moncada and J. R. Vane pp 591 - 593; DOI: 10.1021/jm00180a001 |
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Aporphines. 30. (-)-N-(2-Chloroethyl)-10,11-dihydroxynoraporphine (chloroethylnorapomorphine), novel irreversible dopamine receptor antagonist J. L. Neumeyer, S. J. Law, R. J. Baldessarini, and N. S. Kula pp 594 - 595; DOI: 10.1021/jm00180a002 |
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Structure-activity analyzed by pattern recognition: the asymmetric case W. J. Dunn and Svante Wold pp 595 - 599; DOI: 10.1021/jm00180a003 |
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Quantitative structure-activity relationships by distance geometry: systematic analysis of dihydrofolate reductase inhibitors Gordon M. Crippen pp 599 - 606; DOI: 10.1021/jm00180a004 |
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Quantitative structure-pharmacokinetic relationships derived on antibacterial sulfonamides in rats and its comparison to quantitative structure-activity relationships J. K. Seydel, D. Trettin, H. P. Cordes, O. Wassermann, and M. Malyusz pp 607 - 613; DOI: 10.1021/jm00180a005 |
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Pronounced pharmacological differences arising from minor structural changes in conformationally defined amphetamine analogs. Comparative evaluation of endo- and exo-2-amino- and endo- and exo-2-(methylamino)benzobicyclo[2.2.1]heptene and -benzobicyclo[2.2.2]octene analogs. Conformationally defined adrenergic agents. 4 Gary L. Grunewald, Thomas J. Reitz, Augusta Hallett, Charles O. Rutledge, Sheila Vollmer, James M. Archuleta, and James A. Ruth pp 614 - 620; DOI: 10.1021/jm00180a006 |
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Synthesis and .beta.-adrenergic blocking activity of new aliphatic oxime ethers Gerard Leclerc, Nicole Bieth, and Jean Schwartz pp 620 - 624; DOI: 10.1021/jm00180a007 |
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Adrenergic receptor agonists Kurt Loevgren, Anders Hedberg, and J. Lars G. Nilsson pp 624 - 627; DOI: 10.1021/jm00180a008 |
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Synthesis and antineoplastic activity of hydroquinone dialdehydes Edward M. Newman, Ai Jeng Lin, and Alan C. Sartorelli pp 627 - 631; DOI: 10.1021/jm00180a009 |
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Synthesis and antineoplastic activity of phenyl-substituted phenylsulfonylhydrazones of 1-pyridinecarboxaldehyde 1-oxide William Loh, Lucille A. Cosby, and Alan C. Sartorelli pp 631 - 634; DOI: 10.1021/jm00180a010 |
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Neuroleptic activity in 5-aryltetrahydro-.gamma.-carbolines Charles A. Harbert, Jacob J. Plattner, Willard M. Welch, Albert Weissman, and B. Kenneth Koe pp 635 - 643; DOI: 10.1021/jm00180a011 |
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8-Chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines with substituents at C-4 Jackson B. Hester, Allan D. Rudzik, and Philip F. VonVoigtlander pp 643 - 647; DOI: 10.1021/jm00180a012 |
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Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines Arnold Brossi, Kenner C. Rice, Ching-Pong Mak, Juergen Reden, Arthur E. Jacobson, Yuthasak Nimitkitpaisan, Phil Skolnick, and John Daly pp 648 - 652; DOI: 10.1021/jm00180a013 |
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Acylthioxanthenes: agents which selectively reduce decerebrate rigidity in the cat Michael J. Ashton, Robert F. Chapman, and Anthony H. Loveless pp 653 - 657; DOI: 10.1021/jm00180a014 |
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Alkylating nucleosides. 4. Synthesis and cytostatic activity of chloro- and iodomethylpyrazole nucleosides M. Teresa Garcia Lopez, M. Jose Dominguez, Rosario Herranz, Rosa M. Sanchez-Perez, Antonio Contreras, and Gregorio Alonso pp 657 - 660; DOI: 10.1021/jm00180a015 |
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Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antivirial effects and thymidylate synthetase inhibition Joon Sup Park, Charles T. C. Chang, Charles L. Schmidt, Yechiel Golander, Erik De Clercq, Johan Descamps, and Mathias P. Mertes pp 661 - 665; DOI: 10.1021/jm00180a016 |
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N-(.alpha.-hydroxyalkanoyl) derivatives of Leu-Val-Phe-OCH3 as inhibitors of renin Rodney L. Johnson pp 666 - 669; DOI: 10.1021/jm00180a017 |
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Metabolic depropargylation and its relationship to aldehyde dehydrogenase inhibition in vivo Frances N. Shirota, Eugene G. DeMaster, James A. Elberling, and Herbert T. Nagasawa pp 669 - 673; DOI: 10.1021/jm00180a018 |
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Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones Gavril W. Pasternak and Elliot F. Hahn pp 674 - 676; DOI: 10.1021/jm00180a019 |
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Benzenesulfenamides as antihypertensive agents. Substituted piperidine and 1-arylpiperazine derivatives Sol S. Klioze, Richard C. Allen, Jeffrey C. Wilker, and David L. Woodward pp 677 - 679; DOI: 10.1021/jm00180a020 |
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Synthesis and analgesic properties of some conformationally restricted analogs of profadol Peter A. Crooks and Richard Szyndler pp 679 - 682; DOI: 10.1021/jm00180a021 |
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Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability Victor A. Levin pp 682 - 684; DOI: 10.1021/jm00180a022 |
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Effects of platinum complexes on chymotrypsin P. Melius, Laura A. Andersson, and Y. Y. Lee pp 685 - 687; DOI: 10.1021/jm00180a023 |
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Some spiro analogs of the potent analgesic ketobemidone M. E. Rogers, D. S. Wilkinson, J. R. Thweatt, and S. P. Halenda pp 688 - 690; DOI: 10.1021/jm00180a024 |
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Synthesis and diuretic profile of 3-(3-amino-1,2,4-oxadiazol-5-yl)-5-chloro-2,6-pyrazinediamine, an amiloride-type diuretic Jeffrey W. H. Watthey, Mahesh Desai, Richard Rutledge, and Ronald Dotson pp 690 - 692; DOI: 10.1021/jm00180a025 |
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Effect of changing the COOH-terminal amide group present in the hydrophilic cluster of oxytocin to dimethylamide Yuan Fen Ting, Clark W. Smith, Glenn L. Stahl, Roderich Walter, Paul Cordopatis, and Dimitrios Theodoropoulos pp 693 - 695; DOI: 10.1021/jm00180a026 |
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N-Acetyl-[2-(O-methyl)tyrosine]arginine-vasopressin, an interesting antagonist of the vasopressor response to vasopressin David A. Jones and Wilbur H. Sawyer pp 696 - 698; DOI: 10.1021/jm00180a027 |
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14-(Arylhydroxyamino)codeinones and derivatives as analgetics and antagonists Linda S. Schwab pp 698 - 702; DOI: 10.1021/jm00180a028 |
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New anticonvulsants: Schiff bases of .gamma.-aminobutyric acid and .gamma.-aminobutyramide Jean Pierre Kaplan, Bernard M. Raizon, Michel Desarmenien, Paul Feltz, P. Max Headley, Paul Worms, Kenneth G. Lloyd, and Giuseppe Bartholini pp 702 - 704; DOI: 10.1021/jm00180a029 |
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Neuroleptic 4-aryltetrahydropyrrolo[3,4-b]indoles Willard M. Welch, Charles A. Harbert, and Albert Weissman pp 704 - 707; DOI: 10.1021/jm00180a030 |
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Book Reviews pp 707 - 712; DOI: 10.1021/jm00180a600 |
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Synthesis of 1,3-diazepin-2-one nucleosides as transition-state inhibitors of cytidine deaminase Victor E. Marquez, Paul S. Liu, James A. Kelley, John S. Driscoll, and John J. McCormack pp 713 - 715; DOI: 10.1021/jm00181a001 |
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Prostaglandins and congeners. 25. Inhibition of gastric acid secretion. Replacement of the carboxylate moiety of a prostaglandin with a hydroxymethylketo functional group Allan Wissner, Jay E. Birnbaum, and Donald E. Wilson pp 715 - 717; DOI: 10.1021/jm00181a002 |
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Synthesis and blood pressure lowering activity of 3-(substituted-amino)-1,2,4-benzothiadiazine 1-oxide derivatives Robert D. Dillard, Terence T. Yen, Paul Stark, and Donald E. Pavey pp 717 - 722; DOI: 10.1021/jm00181a003 |
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Synthesis and biochemical screening of phenylselenium-substituted steroid hormones Joseph P. Konopelski, Carl Djerassi, and J. P. Raynaud pp 722 - 726; DOI: 10.1021/jm00181a004 |
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Synthesis and analgesic activity of some 5-(4-hydroxyphenyl)-2-azabicyclo[3.2.1]octanes Helen H. Ong, V. Brian Anderson, Jeffrey C. Wilker, Theodore C. Spaulding, and Laurence R. Meyerson pp 726 - 729; DOI: 10.1021/jm00181a005 |
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Antiinflammatory effects of some copper complexes D. H. Brown, W. E. Smith, J. W. Teape, and A. J. Lewis pp 729 - 734; DOI: 10.1021/jm00181a006 |
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2-Substituted azole derivatives. 1. Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles Goro Tsukamoto, Koichiro Yoshino, Toshihiko Kohno, Hiroshi Ohtaka, Hajime Kagaya, and Keizo Ito pp 734 - 738; DOI: 10.1021/jm00181a007 |
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Synthesis and structure-activity relationships among .alpha.-adrenergic receptor agonists of the phenylethanolamine type Gerard Leclerc, Jean Claude Bizec, Nicole Bieth, and Jean Schwartz pp 738 - 744; DOI: 10.1021/jm00181a008 |
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Comparison of biological effects of N-alkylated congeners of .beta.-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene Joseph G. Cannon, Julio A. Perez, Jonathan P. Pease, John Paul Long, Jan R. Flynn, David B. Rusterholz, and Stuart E. Dryer pp 745 - 749; DOI: 10.1021/jm00181a009 |
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Derivatives of 5-hydroxy-6-methyl-2-aminotetralin Joseph G. Cannon, Dale L. Koble, John Paul Long, and Turkiz Verimer pp 750 - 754; DOI: 10.1021/jm00181a010 |
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Conformationally defined aromatic amino acids. Synthesis and stereochemistry of 2-endo- and 2-exo-amino-1,2,3,4-tetrahydro-1,4-ethanonaphthalene-2-carboxylic acids (2-endo- and 2-exo-aminobenzobicyclo[2.2.2]octene-2-carboxylic acids) Gary L. Grunewald, Simon H. Kuttab, Michael A. Pleiss, James B. Mangold, and Phyllis Soine pp 754 - 758; DOI: 10.1021/jm00181a011 |
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Bradykinin analogs containing N.alpha.-methyl amino acids Robert H. Mazur, Patricia A. James, David A. Tyner, E. Ann Hallinan, John H. Sanner, and Renata Schulze pp 758 - 763; DOI: 10.1021/jm00181a012 |
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Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzodiazepines Kentaro Hirai, Teruyuki Ishiba, Hirohiko Sugimoto, Kazuyuki Sasakura, Toshio Fujishita, Tatsuro Toyoda, Yuji Tsukinoki, Hirokuni Joyama, Hisao Hatakeyama, and Katsumi Hirose pp 764 - 773; DOI: 10.1021/jm00181a013 |
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Inhibitors of indoleethylamine N-methyltransferase. Derivatives of 3-methyl-2-thiazolidinimine. In vitro, in vivo, and metabolic studies Joshua Rokach, Yves Girard, Pierre Hamel, Grant Reader, C. Stanley Rooney, Lewis R. Mandel, Edward J. Cragoe, and Anthony G. Zacchei pp 773 - 780; DOI: 10.1021/jm00181a014 |
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Inhibition of ribosomal peptidyltransferase with 2'(3')-O-acetyl-2"(3")-O-glycyl-1,2-di(adenosin-N6-yl)ethane and -1,4-di(adenosin-N6-yl)butane. Effect of alkyl chain length Masayoshi Murata, Prakash Bhuta, James Owens, and Jiri Zemlicka pp 781 - 786; DOI: 10.1021/jm00181a015 |
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Diaryl amidine derivatives as oncornaviral DNA polymerase inhibitors E. De Clercq and O. Dann pp 787 - 795; DOI: 10.1021/jm00181a016 |
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Heat-induced formation of .alpha.,.beta.-unsaturated nucleoside dialdehydes and their activity with adenosine deaminase Alan J. Grant and Leon M. Lerner pp 795 - 798; DOI: 10.1021/jm00181a017 |
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Novel antitumor nitrosoureas and related compounds and their reactions with DNA J. William Lown, Alummoottil V. Joshua, and Larry W. McLaughlin pp 798 - 805; DOI: 10.1021/jm00181a018 |
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Potential prophylactic antitumor activity of retinylidene 1,3-diketones Nancy Acton, Arnold Brossi, Dianne L. Newton, and Michael B. Sporn pp 805 - 809; DOI: 10.1021/jm00181a019 |
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Simple .beta.-lactam compounds derived from 6-aminopenicillanic acid John C. Sheehan, Seiji Shibahara, and Elsie Chacko pp 809 - 811; DOI: 10.1021/jm00181a020 |
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Conversion of ergolines to hexahydro- and octahydrobenzo[f]quinolines (depyrroloergolines) Nicholas J. Bach, Edmund C. Kornfeld, James A. Clemens, and E. Barry Smalstig pp 812 - 814; DOI: 10.1021/jm00181a021 |
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Book Reviews pp 815 - 818; DOI: 10.1021/jm00181a600 |
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Synthetic immunostimulants derived from the bacterial cell wall Edgar Lederer pp 819 - 825; DOI: 10.1021/jm00182a001 |
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Prevention of Ames test mutagenicity by chemical modification in a series of monoamine oxidase inhibitors M. Harfenist pp 825 - 827; DOI: 10.1021/jm00182a002 |
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Thrombin inhibitors. 1. Ester derivatives of N.alpha.-(arylsulfonyl)-L-arginine Shosuke Okamoto, Kiyokatsu Kinjo, Akiko Hijikata, Ryoji Kikumoto, Yoshikuni Tamao, Kazuo Ohkubo, and Shinji Tonomura pp 827 - 830; DOI: 10.1021/jm00182a003 |
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Thrombin inhibitors. 2. Amide derivatives of N.alpha.-substituted L-arginine Ryoji Kikumoto, Yoshikuni Tamao, Kazuo Ohkubo, Tohru Tezuka, Shinji Tonomura, Shosuke Okamoto, Yoshinori Funahara, and Akiko Hijikata pp 830 - 836; DOI: 10.1021/jm00182a004 |
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Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 2. 1,2,3,4-Tetrahydroisoquinoline-7-sulfonanilides Benjamin Blank, Arnold J. Krog, Gilbert Weiner, and Robert G. Pendleton pp 837 - 840; DOI: 10.1021/jm00182a005 |
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Antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,1,2,2-tetraalkyl-1,2-diphenylethanes Rolf W. Hartmann, Gerhard Kranzfelder, Erwin Von Angerer, and Helmut Schoenenberger pp 841 - 848; DOI: 10.1021/jm00182a006 |
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Synthesis of nitrosourea derivatives of pyridine and piperidine as potential anticancer agents A. Michael Crider, Randall Lamey, Heinz G. Floss, John M. Cassady, and William J. Bradner pp 848 - 851; DOI: 10.1021/jm00182a007 |
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Fluorinated pyrimidine nucleosides. 4. Synthesis and antitumor testing of a series of 2',5'-dideoxy- and 2',3',5'-trideoxynucleosides of 5-fluorouracil A. F. Cook, M. J. Holman, and M. J. Kramer pp 852 - 857; DOI: 10.1021/jm00182a008 |
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Antihypertensive ureidopiperidines J. L. Archibald, D. R. Beardsley, G. M. F. Bisset, P. Fairbrother, J. L. Jackson, A. Opalko, and T. J. Ward pp 857 - 861; DOI: 10.1021/jm00182a009 |
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Effects of phosphonium compounds on Schistosoma mansoni Patrick R. McAllister, Mary J. Dotson, Samuel O. Grim, and Gilbert R. Hillman pp 862 - 865; DOI: 10.1021/jm00182a010 |
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Conformationally restricted tricyclic antidepressants. 1. Octahydrodibenzazepinonaphthyridines as rigid imipramine analogs Arnold R. Martin, Vidyadhar M. Paradkar, Geoffrey W. Peng, Robert C. Speth, Henry I. Yamamura, and Alan S. Horn pp 865 - 873; DOI: 10.1021/jm00182a011 |
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6-(Substituted-amino)-4H-s-triazolo[4,3-a][1,4]benzodiazepines and 4-(substituted-amino)-6H-s-triazolo[4,3-a][1,4]benzodiazepines with potential antianxiety activity Jackson B. Hester, Philip VonVoigtlander, and Gerald N. Evenson pp 873 - 877; DOI: 10.1021/jm00182a012 |
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Heteroarenobenzodiazepines. 3. 4-Piperazinyl-10H-thieno[2,3-b][1,5]benzodiazepines as potential neuroleptics Jiban K. Chakrabarti, Linda Horsman, Terrence M. Hotten, Ian A. Pullar, David E. Tupper, and Francesca C. Wright pp 878 - 884; DOI: 10.1021/jm00182a013 |
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Heteroarenobenzodiazepines. 4. 10-Piperazinyl-4H-thieno[3,2-b][1,5]- and -[3,4-b][1,5]benzodiazepines as potential neuroleptics Jiban K. Chakrabarti, John Fairhurst, Norman J. A. Gutteridge, Linda Horsman, Ian A. Pullar, Colin W. Smith, David J. Steggles, David E. Tupper, and Francesca C. Wright pp 884 - 889; DOI: 10.1021/jm00182a014 |
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Ultraviolet photoelectron spectroscopy of cyclic amidines. 2. Electronic structure of clonidine and some related 2-(phenylimino)imidazolidines with .alpha.-adrenergic activity A. P. De Jong and H. Van Dam pp 889 - 895; DOI: 10.1021/jm00182a015 |
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4-Anilidopiperidine analgesics. 3. 1-Substituted 4-(propananilido)perhydroazepines as ring-expanded analogs Z. Gail Finney and Thomas N. Riley pp 895 - 899; DOI: 10.1021/jm00182a016 |
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Folate analogs altered in the C9-N10 bridge region. 16. Synthesis and antifolate activity of 11-thiohomoaminopterin M. G. Nair, Shiang-Yuan Chen, Roy L. Kisliuk, Y. Gaumont, and D. Strumpf pp 899 - 903; DOI: 10.1021/jm00182a017 |
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Prostaglandins and congeners. 22. Synthesis of 11-substituted derivatives of 11-deoxyprostaglandins E1 and E2. Potential bronchodilators M. Brawner Floyd, Robert E. Schaub, Gerald J. Siuta, Jerauld S. Skotnicki, Charles V. Grudzinskas, Martin J. Weiss, Franz Dessy, and L. VanHumbeeck pp 903 - 913; DOI: 10.1021/jm00182a018 |
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Anticandidal activity of pyrimidine-peptide conjugates Jen-Shing Ti, Alvin S. Steinfeld, Fred Naider, Ali Gulumoglu, Sam V. Lewis, and Jeffrey M. Becker pp 913 - 918; DOI: 10.1021/jm00182a019 |
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Metabolism of 6-substituted benzo[a]pyrene derivatives: O-dealkylation and regiospecificity in aromatic hydroxylation Andrew J. Alpert and Ercole L. Cavalieri pp 919 - 927; DOI: 10.1021/jm00182a020 |
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Studies on cardiovascular agents. 6. Synthesis and coronary vasodilating and antihypertensive activities of 1,2,4-triazolo[1,5-a]pyrimidines fused to heterocyclic systems Yasunobu Sato, Yasuo Shimoji, Hiroshi Fujita, Hiroshi Nishino, Hiroshi Mizuno, Shinsaku Kobayashi, and Seiji Kumakura pp 927 - 937; DOI: 10.1021/jm00182a021 |
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Conformationally restricted phenothiazine neuroleptics. 1. 3-(Dimethylamino)-1,2,3,4-tetrahydroazepino[3,2,1-kl]phenothiazine Arnold R. Martin, Sun H. Kim, Henry I. Yamamura, and Alan S. Horn pp 938 - 941; DOI: 10.1021/jm00182a022 |
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Crystal and molecular structure of nafoxidine and stereochemical features of anticancer antiestrogens Norman Camerman, Lilian Y. Y. Chan, and Arthur Camerman pp 941 - 945; DOI: 10.1021/jm00182a023 |
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Experimental antiulcer drugs. 4. 1,3-Disubstituted 2,4,5,6-tetrahydro-4,6,6-trimethyl-2-phenylcyclopenta[c]pyrrole-4-carboxamides Rudolf Oesterlin, Malcolm R. Bell, Allan G. Hlavac, Ruthann H. McGarry, Karl O. Gelotte, James C. Bradford, and Janis Rozitis pp 945 - 948; DOI: 10.1021/jm00182a024 |
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4a,9b-trans-8-Fluoro-5-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-4-hydroxybutyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole hydrochloride, a new potent neuroleptic Willard M. Welch, Frank E. Ewing, Charles A. Harbert, Albert Weissman, and B. Kenneth Koe pp 949 - 952; DOI: 10.1021/jm00182a025 |
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Synthesis and anxiolytic activity of a series of pyrazino[1,2-a][1,4]benzodiazepine derivatives R. G. Smith, R. A. Lucas, and J. W. F. Wasley pp 952 - 955; DOI: 10.1021/jm00182a026 |
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Nitrobenzyl halides and carbamates as prototype bioreductive alkylating agents Beverly A. Teicher and Alan C. Sartorelli pp 955 - 960; DOI: 10.1021/jm00182a027 |
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Synthesis and preliminary binding studies of 4,4-ditritio-(-)-nicotine of high specific activity William C. Vincek, Billy R. Martin, Mario D. Aceto, and E. R. Bowman pp 960 - 962; DOI: 10.1021/jm00182a028 |
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Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines Chikao Nakayama, Yusuke Wataya, Rich B. Meyer, Daniel V. Santi, Mineo Saneyoshi, and Tohru Ueda pp 962 - 964; DOI: 10.1021/jm00182a029 |
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Antiallergy activity of 10-oxo-10H-pyridazino[6,1-b]quinazoline-2-carboxylic acids Charles F. Schwender, Brooks R. Sunday, Joseph J. Kerbleski, and David J. Herzig pp 964 - 966; DOI: 10.1021/jm00182a030 |
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Book Reviews pp 966 - 972; DOI: 10.1021/jm00182a600 |
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Separation of potent central and renal dopamine agonist activity in substituted 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepines Joseph Weinstock, James W. Wilson, David L. Ladd, Charles K. Brush, Francis R. Pfeiffer, George Y. Kuo, Kenneth G. Holden, Nelson C. F. Yim, Richard A. Hahn, and et al. pp 973 - 975; DOI: 10.1021/jm00183a001 |
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6-(Phenylthio)-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines, a novel class of dopamine receptor antagonists and neuroleptics Carl Kaiser, Fadia E. Ali, William E. Bondinell, Martin Brenner, Kenneth G. Holden, Thomas W. Ku, Hye-Ja Oh, Stephen T. Ross, Nelson C. F. Yim, and et al. pp 975 - 976; DOI: 10.1021/jm00183a002 |
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Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity Charles R. Ellefson, Kathleen A. Prodan, Linda R. Brougham, and Arni Miller pp 977 - 980; DOI: 10.1021/jm00183a003 |
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Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents Maurice P. LaMontagne, Dinesh Dagli, M. Sami Khan, and Peter Blumbergs pp 981 - 985; DOI: 10.1021/jm00183a004 |
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Synthesis and biological activity of fluoroalkylamine derivatives of narcotic analgesics William G. Reifenrath, Edward B. Roche, Walid A. Al-Turk, and Howard L. Johnson pp 985 - 990; DOI: 10.1021/jm00183a005 |
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Demethyl analogs of psychoactive methoxyphenalkylamines: synthesis and serotonin receptor affinities Richard A. Glennon, Stephen M. Liebowitz, Dianne Leming-Doot, and John A. Rosecrans pp 990 - 994; DOI: 10.1021/jm00183a006 |
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Estrogen receptor-based imaging agents. 1. Synthesis and receptor binding affinity of some aromatic and D-ring halogenated estrogens Daniel F. Heiman, Stephen G. Senderoff, John A. Katzenellenbogen, and Richard J. Neeley pp 994 - 1002; DOI: 10.1021/jm00183a007 |
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Estrogen receptor based imaging agents. 2. Synthesis and receptor binding affinity of side-chain halogenated hexestrol derivatives Ramanuj Goswami, Stephen G. Harsy, Daniel F. Heiman, and John A. Katzenellenbogen pp 1002 - 1008; DOI: 10.1021/jm00183a008 |
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Aporphines. 31. Synthesis and antitumor activity of aporphine nitrogen mustards John L. Neumeyer, Felix E. Granchelli, Crist N. Filer, Albert H. Soloway, and Say-Jong Law pp 1008 - 1013; DOI: 10.1021/jm00183a009 |
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Retinoic acid analogs. Synthesis and potential as cancer chemopreventive agents Marcia I. Dawson, Peter D. Hobbs, Karl Kuhlmann, Victor A. Fung, C. Tucker Helmes, and Wan-Ru Chao pp 1013 - 1022; DOI: 10.1021/jm00183a010 |
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Evaluation of rotenone and related compounds as antagonists of slow-reacting substance of anaphylaxis Richard J. Ashack, Leslie P. McCarty, Rebecca S. Malek, Frank R. Goodman, and Norton P. Peet pp 1022 - 1026; DOI: 10.1021/jm00183a011 |
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Bronchodilator and antiulcer phenoxypyrimidinones C. A. Lipinski, J. G. Stam, J. N. Pereira, N. R. Ackerman, and H. J. Hess pp 1026 - 1031; DOI: 10.1021/jm00183a012 |
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Synthesis of .alpha.-methylene-.gamma.-butyrolactones: a structure-activity relationship study of their allergenic power Gilbert Schlewer, Jean Luc Stampf, and Claude Benezra pp 1031 - 1038; DOI: 10.1021/jm00183a013 |
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Metabolic N-hydroxylation. Use of substituent variation to modulate the in vitro bioactivation of 4-acetamidostilbenes Patrick E. Hanna, Richard E. Gammans, Russell D. Sehon, and Man-Kil Lee pp 1038 - 1044; DOI: 10.1021/jm00183a014 |
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Resolution, absolute configuration, and antiarrhythmic properties of the enantiomers of disopyramide, 4-(diisopropylamino)-2-(2-pyridyl)-2-phenylbutyramide Terrence R. Burke, Wendel L. Nelson, Margaret Mangion, Gilbert J. Hite, Corwin M. Mokler, and Peter C. Ruenitz pp 1044 - 1048; DOI: 10.1021/jm00183a015 |
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Structure-activity relationship of diphenylthiourea antivirals Angel S. Galabov, Boris S. Galabov, and Nadejda A. Neykova pp 1048 - 1051; DOI: 10.1021/jm00183a016 |
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Tumor inhibitory triazenes. 2. Variation of antitumor activity within an homologous series Derry E. V. Wilman and Phyllis M. Goddard pp 1052 - 1054; DOI: 10.1021/jm00183a017 |
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Antileukemic compounds derived from the chemical modification of macrocyclic trichothecenes. 1. Derivatives of verrucarin A Bruce B. Jarvis, G. Patrick Stahly, Gowsala Pavanasasivam, and Eugene P. Mazzola pp 1054 - 1058; DOI: 10.1021/jm00183a018 |
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1-[(Ethoxyamino)methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepins: a new class of antianaphylactic agents Ruth E. TenBrink, John M. McCall, and Herbert G. Johnson pp 1058 - 1060; DOI: 10.1021/jm00183a019 |
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Book Reviews pp 1061 - 1062; DOI: 10.1021/jm00183a600 |
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Cancer chemotherapy: congener synthesis John A. Montgomery pp 1063 - 1067; DOI: 10.1021/jm00184a001 |
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Stereochemical requirements for cannabinoid activity R. Mechoulam, N. Lander, T. H. Varkony, I. Kimmel, O. Becker, Z. Ben-Zvi, H. Edery, and G. Porath pp 1068 - 1072; DOI: 10.1021/jm00184a002 |
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Fluoroprostaglandins: synthesis and biological evaluation of the methyl esters of (+)-12-fluoro-, (-)-ent-12-fluoro-, (+)-15-epi-fluoro-, and (-)-ent-15-epi-12-fluoroprostaglandin F2.alpha. Paul A. Grieco, William Owens, C. L. J. Wang, Eric Williams, William J. Schillinger, Ken Hirotsu, and Jon Clardy pp 1072 - 1077; DOI: 10.1021/jm00184a003 |
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Carbon-14 fluorinated prostaglandins: synthesis and biological evaluation of the methyl esters of (+)-14-fluoro-, (+)-15-epi-14-fluoro-, (+)-13(E)-14-fluoro-, and (+)-13(E)-15-epi-14-fluoroprostaglandin F2.alpha. Paul A. Grieco, William J. Schillinger, and Yuusaku Yokoyama pp 1077 - 1083; DOI: 10.1021/jm00184a004 |
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Anticoccidial derivatives of 6-azauracil. 3. Synthesis, high activity, and short plasma half-life of 1-phenyl-6-azauracils containing sulfonamide substituents Max W. Miller, Banavara L. Mylari, Harold L. Howes, Sanford K. Figdor, Martin J. Lynch, John E. Lynch, and Richard C. Koch pp 1083 - 1087; DOI: 10.1021/jm00184a005 |
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Nucleosides. 116. 1-(.beta.-D-Xylofuranosyl)-5-fluorocytosines with a leaving group on the 3' position. Potential double-barreled masked precursors of anticancer nucleosides K. A. Watanabe, U. Reichman, C. K. Chu, D. H. Hollenberg, and J. J. Fox pp 1088 - 1094; DOI: 10.1021/jm00184a006 |
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Antitumor structure-activity relationships. Nitrosoureas vs. L-1210 leukemia Corwin Hansch, A. Leo, Charles Schmidt, P. Y. C. Jow, and John A. Montgomery pp 1095 - 1101; DOI: 10.1021/jm00184a007 |
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Synthesis and antiarrhythmic activity of .alpha.,.alpha.-bis[(dialkylamino)alkyl]phenylacetamides Peter K. Yonan, Robert L. Novotney, Chi Min Woo, Kathleen A. Prodan, and Fred M. Hershenson pp 1102 - 1108; DOI: 10.1021/jm00184a008 |
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Synthesis and antibacterial activity of new 1-oxa-1-dethiacephalosporins Daijiro Hagiwara, Hidekazu Takeno, Matsuhiko Aratani, Keiji Hemmi, and Masashi Hashimoto pp 1108 - 1113; DOI: 10.1021/jm00184a009 |
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Novel analogs of enkephalin: identification of functional groups required for biological activity Fredric A. Gorin, T. M. Balasubramanian, Theodore J. Cicero, John Schwietzer, and Garland R. Marshall pp 1113 - 1122; DOI: 10.1021/jm00184a010 |
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.beta.-Adrenergic blocking agents. 20. (3-Hydroxyprop-1-enyl)-substituted 1-(aryloxy)-3-(alkylamino)propan-2-ols H. Tucker pp 1122 - 1126; DOI: 10.1021/jm00184a011 |
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Synthesis of selenium-75 labeled tertiary diamines: new brain imaging agents Hank Kung and Monte Blau pp 1127 - 1130; DOI: 10.1021/jm00184a012 |
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Synthesis, absorption, and toxicity of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator Raymond J. Bergeron, Philip S. Burton, Kathy Ann McGovern, Erica J. St. Onge, and Richard R. Streiff pp 1130 - 1133; DOI: 10.1021/jm00184a013 |
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Ivermectin, a new broad-spectrum antiparasitic agent John C. Chabala, Helmut Mrozik, Richard L. Tolman, Philip Eskola, Aino Lusi, Louis H. Peterson, Mary F. Woods, Michael H. Fisher, William C. Campbell, and et al. pp 1134 - 1136; DOI: 10.1021/jm00184a014 |
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Synthesis of potential inhibitors of hypoxanthine-guanine phosphoribosyltransferase for testing as antiprotozoal agents. 2. 1-Substituted hypoxanthines James R. Piper, Anne G. Laseter, Thomas P. Johnston, and John A. Montgomery pp 1136 - 1139; DOI: 10.1021/jm00184a015 |
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Studies on antimicrobial agents. 1. Synthesis and relation between the antimicrobial activities and certain physicochemical properties of some N'-(pyridinioacetyl) fatty acid hydrazides Susana M. Sicardi, Carlos M. Vega, and Eberhard B. Cimijotti pp 1139 - 1142; DOI: 10.1021/jm00184a016 |
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(.+-.)-trans-2-(Aminomethyl)cyclobutanecarboxylic acid hydrochloride: a rigid analog of .gamma.-aminobutyric acid John P. O'Donnell, David A. Johnson, and Albert J. Azzaro pp 1142 - 1144; DOI: 10.1021/jm00184a017 |
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Structure-activity relationships of pyrrole amidine antiviral antibiotics. 2. Preparation of mono- and tripyrrole derivatives of congocidine Meir Bialer, Boris Yagen, Raphael Mechoulam, and Yechiel Becker pp 1144 - 1148; DOI: 10.1021/jm00184a018 |
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Book Reviews pp 1148 - 1152; DOI: 10.1021/jm00184a600 |
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Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines C. Roger Fernando, Ian C. Calder, and Kathryn N. Ham pp 1153 - 1158; DOI: 10.1021/jm00185a001 |
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Synthesis of certain [6:5:6] linear tricyclic nucleosides as potential antitumor agents Fung-Lung Chung, Karl H. Schram, Raymond P. Panzica, Robert A. Earl, Linda L. Wotring, and Leroy B. Townsend pp 1158 - 1166; DOI: 10.1021/jm00185a002 |
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Amino acid and dipeptide derivatives of daunorubicin. 1. Synthesis, physicochemical properties, and lysosomal digestion Michele Masquelier, Roger Baurain, and Andre Trouet pp 1166 - 1170; DOI: 10.1021/jm00185a003 |
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Amino acid and dipeptide derivatives of daunorubicin. 2. Cellular pharmacology and antitumor activity of L1210 leukemic cells in vitro and in vivo R. Baurain, M. Masquelier, D. Deprez-De Campeneere, and A. Trouet pp 1171 - 1174; DOI: 10.1021/jm00185a004 |
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Metabolic .beta.-hydroxylation and N-oxidation of n'-nitrosonornicotine Stephen S. Hecht, Chi-Hong B. Chen, and Dietrich Hoffmann pp 1175 - 1178; DOI: 10.1021/jm00185a005 |
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Urinary metabolites of timolol from humans and laboratory animals. Syntheses and .beta.-adrenergic blocking activities B. K. Wasson, J. Scheigetz, C. S. Rooney, R. A. Hall, N. N. Share, W. J. A. VandenHeuvel, B. H. Arison, O. D. Hensens, R. L. Ellsworth, and D. J. Tocco pp 1178 - 1184; DOI: 10.1021/jm00185a006 |
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Glycolipids as potential immunologic adjuvants Mitree M. Ponpipom, Robert L. Bugianesi, and Tsung-Ying Shen pp 1184 - 1188; DOI: 10.1021/jm00185a007 |
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Substituted 6,7-dihydroimidazo[1,2-a]purin-9(4H)-ones D. L. Temple, J. P. Yevich, J. D. Catt, D. Owens, C. Hanning, R. R. Covington, R. J. Seidehamel, and K. W. Dungan pp 1188 - 1198; DOI: 10.1021/jm00185a008 |
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Antimalarials. 12. Preparation of carbon isosteres of selected 4-pyridinemethanols as suppressive antimalarials Anica Markovac and Maurice P. LaMontagne pp 1198 - 1201; DOI: 10.1021/jm00185a009 |
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Confidence interval estimators for parameters associated with quantitative structure-activity relationships Stephen W. Dietrich, Nicholas D. Dreyer, Corwin Hansch, and Donald L. Bentley pp 1201 - 1205; DOI: 10.1021/jm00185a010 |
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Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines Stephen W. Dietrich, Jeffrey M. Blaney, Mark A. Reynolds, Priscilla Y. C. Jow, and Corwin Hansch pp 1205 - 1212; DOI: 10.1021/jm00185a011 |
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Structure-activity relationship in a series of newly synthesized 1-amino-substituted ellipticine derivatives Claire Ducrocq, Francoise Wendling, Jean Claude Chermann, Martine Tourbez-Perrin, Christian Rivalle, Pierre Tambourin, Francois Pochon, and Emile Bisagni pp 1212 - 1216; DOI: 10.1021/jm00185a012 |
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Chemistry, pharmacology, and structure-activity relationships with a new type of imidazolines exerting a specific bradycardic action at a cardiac site Helmut Staehle, Helmut Daniel, Walter Kobinger, Christian Lillie, and Ludwig Pichler pp 1217 - 1222; DOI: 10.1021/jm00185a013 |
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Studies on several 7-substituted N,N-dimethyltryptamines R. A. Glennon, E. Schubert, J. M. Jacyno, and J. A. Rosecrans pp 1222 - 1226; DOI: 10.1021/jm00185a014 |
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Fluorinated analogs of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea: an attempt to control metabolism Allan B. Foster, Michael Jarman, Paul L. Coe, John Sleigh, and J. Colin Tatlow pp 1226 - 1229; DOI: 10.1021/jm00185a015 |
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Synthesis and biological activity of 5-fluoro-2'-deoxyuridine 5'-phosphorodiamidates Mary E. Phelps, Peter W. Woodman, and Peter V. Danenberg pp 1229 - 1232; DOI: 10.1021/jm00185a016 |
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Optically active derivatives of imidazolines. .alpha.-Adrenergic blocking properties Fu-Lian Hsu, Akihiko Hamada, Mark E. Booher, H. Fuder, P. N. Patil, and Duane D. Miller pp 1232 - 1235; DOI: 10.1021/jm00185a017 |
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Synthesis and antineoplastic activity of a novel series of phosphoramide mustard analogs of pyrimidine deoxyribonucleosides Tai-Shun Lin, Paul H. Fischer, and William H. Prusoff pp 1235 - 1237; DOI: 10.1021/jm00185a018 |
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2-Methylanthraquinone derivatives as potential bioreductive alkylating agents Tai-Shun Lin, Beverly A. Tiecher, and Alan C. Sartorelli pp 1237 - 1242; DOI: 10.1021/jm00185a019 |
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8-Hydroxyanthracyclinones from .epsilon.-rhodomycinone Horng-Jau Lin, Virendra Kumar, and William A. Remers pp 1242 - 1244; DOI: 10.1021/jm00185a020 |
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Chemistry of nitrosoureas. Intermediacy of 4,5-dihydro-1,2,3-oxadiazole in 1,3-bis(2-chloroethyl)-1-nitrosourea decomposition Robert B. Brundrett pp 1245 - 1247; DOI: 10.1021/jm00185a021 |
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Inhibition of dihydrofolate reductase. 3. 4,6-Diamino-1,2-dihydro-2,2-dimethyl-1-(2-substituted-phenyl)-s-triazine inhibition of bovine liver and mouse tumor enzymes Ki Hwan Kim, Stephen W. Dietrich, Corwin Hansch, Bruce J. Dolnick, and Joseph R. Bertino pp 1248 - 1251; DOI: 10.1021/jm00185a022 |
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Synthesis and antiallergy activity of 4-oxopyrano[3,2-b]indoles Paul C. Unangst, Richard E. Brown, and David J. Herzig pp 1251 - 1255; DOI: 10.1021/jm00185a023 |
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Antiarrhythmic activity of amitriptyline analogues in conscious dogs after myocardial infarction: cyproheptadinium methiodide R. Douglas Wilkerson and James D. Henderson pp 1255 - 1258; DOI: 10.1021/jm00185a024 |
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Synthesis and some pharmacological properties of [8-L-tryptophan]oxytocin Miklos Bodanszky, John C. Tolle, Janny Seto, and Wilbur H. Sawyer pp 1258 - 1261; DOI: 10.1021/jm00185a025 |
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Synthesis and adrenergic blocking effects of 2-(alkylamino)-3,4-dihydroquinazolines John A. Grosso, David E. Nichols, Maxine B. Nichols, and George K. W. Yim pp 1261 - 1264; DOI: 10.1021/jm00185a026 |
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Synthesis and aldose reductase inhibitory activity of 7-sulfamoylxanthone-2-carboxylic acids Jurg R. Pfister, Walter E. Wymann, Janette M. Mahoney, and L. David Waterbury pp 1264 - 1267; DOI: 10.1021/jm00185a027 |
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Synthesis of some 5-phenylhexahydroazepino[4,5-b]indoles as potential neuroleptic agents Arthur J. Elliott, Elijah H. Gold, and Henry Guzik pp 1268 - 1269; DOI: 10.1021/jm00185a028 |
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Book Reviews pp 1270 - 1274; DOI: 10.1021/jm00185a600 |
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Prodrugs and site-specific drug delivery Valentino J. Stella and Kenneth J. Himmelstein pp 1275 - 1282; DOI: 10.1021/jm00186a001 |
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A multifaceted approach to the study of the side-chain conformation in .beta.-lactamase-resistant penicillins Patrick C. Blanpain, Janos B. Nagy, Guy H. Laurent, and Francois V. Durant pp 1283 - 1292; DOI: 10.1021/jm00186a002 |
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Thrombin inhibitors. 3. Carboxyl-containing amide derivatives of N.alpha.-substituted L-arginine Ryoji Kikumoto, Yoshikuni Tamao, Kazuo Ohkubo, Tohru Tezuka, Shinji Tonomura, Shosuke Okamoto, and Akiko Hijikata pp 1293 - 1299; DOI: 10.1021/jm00186a003 |
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Analogs of chloramphenicol: circular dichroism spectra, inhibition of ribosomal peptidyltransferase, and possible mechanism of action Prakash Bhuta, Hsiao L. Chung, Jui-Shung Hwang, and Jiri Zemlicka pp 1299 - 1305; DOI: 10.1021/jm00186a004 |
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3-(4-Piperidinylalkyl)indoles, selective inhibitors of neuronal 5-hydroxytryptamine uptake Claude Gueremy, Francois Audiau, Alain Champseix, Andre Uzan, Gerard Le Fur, and Jean Rataud pp 1306 - 1310; DOI: 10.1021/jm00186a005 |
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Cytotoxic and antitumor properties of bleomycin and several of its metal complexes Eswara A. Rao, Leon A. Saryan, William E. Antholine, and David H. Petering pp 1310 - 1318; DOI: 10.1021/jm00186a006 |
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Synthetic and preliminary hemodynamic and whole animal toxicity studies on (R,S)-, (R)-, and (S)-2-methyl-3-(2,4,5-trihydroxyphenyl)alanine D. G. Musson, D. Karashima, H. Rubiero, K. L. Melmon, A. Cheng, and N. Castagnoli pp 1318 - 1323; DOI: 10.1021/jm00186a007 |
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Studies on the syntheses of heterocyclic compounds. 845. Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives Tetsuji Kametani, Kazuo Kigasawa, Mineharu Hiiragi, Kikuo Wakisaka, Seiji Haga, Yasuo Nagamatsu, Hideo Sugi, Kazunaga Fukawa, Osamu Irino, and et al. pp 1324 - 1329; DOI: 10.1021/jm00186a008 |
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DNA intercalating compounds as potential antitumor agents. 1. Preparation and properties of 7H-pyridocarbazoles Didier Pelaprat, Robert Oberlin, Irene Le Guen, Jean Bernard Le Pecq, and Bernard P. Roques pp 1330 - 1335; DOI: 10.1021/jm00186a009 |
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DNA intercalating compounds as potential antitumor agents. 2. Preparation and properties of 7H-pyridocarbazole dimers Didier Pelaprat, Alain Delbarre, Irene Le Guen, Jean Bernard Le Pecq, and Bernard P. Roques pp 1336 - 1343; DOI: 10.1021/jm00186a010 |
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Nucleoside conjugates as potential antitumor agents. 3. Synthesis and antitumor activity of 1-(.beta.-D-arabinofuranosyl)cytosine conjugates of corticosteroids Chung Il Hong, Alexander Nechaev, Alan J. Kirisits, David J. Buchheit, and Charles R. West pp 1343 - 1347; DOI: 10.1021/jm00186a011 |
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N,N'-Dialkylbis(dichlorophenyl)ethylenediamines and -imidazolidines: relationship between structure and estradiol receptor affinity Erwin Von Angerer, Gerhard Kranzfelder, Ashok K. Taneja, and Helmut Schoenenberger pp 1347 - 1350; DOI: 10.1021/jm00186a012 |
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Synthesis, biological evaluation, and preliminary structure-activity considerations of a series of alkylphenols as intravenous anesthetic agents Roger James and John B. Glen pp 1350 - 1357; DOI: 10.1021/jm00186a013 |
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Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids Hiroshi Koga, Akira Itoh, Satoshi Murayama, Seigo Suzue, and Tsutomu Irikura pp 1358 - 1363; DOI: 10.1021/jm00186a014 |
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Synthesis and immunological activity of 5,6,6a,8,9,11a-hexahydronaphth[1',2':4,5]imidazo[2,1-b]thiazoles and 5,6,6a,9,10,11a-hexahydronaphth[2',1':4,5]imidazo[2,1-b]thiazoles Masahiko Saito, Yasutaka Kayama, Tamaki Watanabe, Hisashi Fukushima, Takeshi Hara, Kazuo Koyano, Akio Takenaka, and Yoshio Sasada pp 1364 - 1372; DOI: 10.1021/jm00186a015 |
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Synthesis and antiallergic properties of some 4H,5H-pyrano[3,2-c][1]benzopyran-4-one, 4H,5H-[1]benzothiopyrano[4,3-b]pyran-4-one, and 1,4-dihydro-5H-[1]benzothiopyrano[4,3-b]pyridin-4-one derivatives Adolf Philipp, Ivo Jirkovsky, and Rene R. Martel pp 1372 - 1376; DOI: 10.1021/jm00186a016 |
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Studies on anticoccidial agents. 13. Synthesis and anticoccidial activity of nitropyridine-2- and -3-sulfonamides and derivatives Yasuhiro Morisawa, Mitsuru Kataoka, Hitoshi Nagahori, Toshiaki Sakamoto, Noritoshi Kitano, Kenichi Kusano, and Kiyoshi Sato pp 1376 - 1380; DOI: 10.1021/jm00186a017 |
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7-(Aminoacyl) and 7-(aminoalkyl) derivatives of 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines as potential antidepressant agents Edward J. Glamkowski, James M. Fortunato, and Harry M. Geyer pp 1380 - 1386; DOI: 10.1021/jm00186a018 |
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Antihypertensive (2-aminoethyl)thiourea derivatives. 1 Jefferson W. Tilley, Paul Levitan, Richard W. Kierstead, and Michael Cohen pp 1387 - 1392; DOI: 10.1021/jm00186a019 |
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Synthesis and biological activity of a ketomethylene analog of a tripeptide inhibitor of angiotensin converting enzyme Ronald G. Almquist, Wan-Ru Chao, Marie E. Ellis, and Howard L. Johnson pp 1392 - 1398; DOI: 10.1021/jm00186a020 |
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Antihypertensive 5,6-diarylpyridazin-3-ones Russell Buchman, James A. Scozzie, Zaven S. Ariyan, Richard D. Heilman, Donna J. Rippin, W. J. Pyne, Larry J. Powers, and Richard J. Matthews pp 1398 - 1405; DOI: 10.1021/jm00186a021 |
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Synthesis and antihypertensive activity of 5-amino-2-pyridinecarboxylic acid derivatives Neville Finch, Thomas R. Campbell, Charles W. Gemenden, and Henry J. Povalski pp 1405 - 1410; DOI: 10.1021/jm00186a022 |
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Synthesis and antifertility activity of 3,9-dihydroxy-5,6,6a.alpha.,6b.beta.,11,12,12a.beta.,12b.alpha.-octahydrodibenzo[a,g]biphenylene, a structural relative of diethylstilbestrol P. H. Ruehle, C. E. Browne, E. H. Vickery, N. R. Beller, E. J. Eisenbraun, R. A. Loghry, and Dick Van der Helm pp 1410 - 1414; DOI: 10.1021/jm00186a023 |
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2-(Aminomethyl)phenols, a new class of saluretic agents. 1. Effects of nuclear substitution G. E. Stokker, A. A. Deana, S. J. DeSolms, E. M. Schultz, R. L. Smith, E. J. Cragoe Jr., J. E. Baer, C. T. Ludden, H. F. Russo, and et al. pp 1414 - 1427; DOI: 10.1021/jm00186a024 |
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Analgesic narcotic antagonists. 4. 7-Methyl-N-(cycloalkylmethyl)-3-hydroxy morphinan-6-one and -isomorphinan-6-one David L. Leland and Michael P. Kotick pp 1427 - 1431; DOI: 10.1021/jm00186a025 |
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Synthesis and structure-function studies of melanocyte stimulating hormone analogs modified in the 2 and 4(7) positions: comparison of activities on frog skin melanophores and melanoma adenylate cyclase Victor J. Hruby, Tomi K. Sawyer, Young C. S. Yang, Marvin D. Bregman, Mac E. Hadley, and Christopher B. Heward pp 1432 - 1437; DOI: 10.1021/jm00186a026 |
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Antihypertensive (2-aminoethyl)thiourea derivatives. 2 Jefferson W. Tilley, H. Ramuz, F. Hefti, and M. Gerold pp 1438 - 1439; DOI: 10.1021/jm00186a027 |
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Synthesis and biological activities of chloroethylurea, methylurea, and nitrosourea analogs of N-deacetylmethylthiocolchicine Tai-Shun Lin, George T. Shiau, William H. Prusoff, and Robert E. Harmon pp 1440 - 1442; DOI: 10.1021/jm00186a028 |
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Crystal structures of calcium channel antagonists: 2,6-dimethyl-3,5-dicarbomethoxy-4-[2-nitro-, 3-cyano-, 4-(dimethylamino)-, and 2,3,4,5,6-pentafluorophenyl]-1,4-dihydropyridine A. M. Triggle, E. Shefter, and D. J. Triggle pp 1442 - 1445; DOI: 10.1021/jm00186a029 |
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Lipophilic and hydrophilic esters of 4-acetyl-2-(2-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one as antihypertensive agents S. W. Fogt, J. A. Scozzie, R. D. Heilman, and L. J. Powers pp 1445 - 1448; DOI: 10.1021/jm00186a030 |
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Some short-chain N6-substituted adenosine analogs with antitumor properties M. H. Fleysher, R. J. Bernacki, and G. A. Bullard pp 1448 - 1452; DOI: 10.1021/jm00186a031 |
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Rational selection of test series. 1. Principal component method combined with multidimensional mapping W. J. Streich, S. Dove, and R. Franke pp 1452 - 1456; DOI: 10.1021/jm00186a032 |
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Rational selection of test series. 2. Two-dimensional mapping of intraclass correlation matrixes S. Dove, W. J. Streich, and R. Franke pp 1456 - 1459; DOI: 10.1021/jm00186a033 |
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Book Reviews pp 1460 - 1462; DOI: 10.1021/jm00186a600 |
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Additions and Corrections - Basic Antiinflammatory Compounds. N,N'N''-Trisubstituted Guanidines. Schneur Rachlin, E. Bramm, I. Ahnfelt-Rønne, and E. Arrigoni-Martelli pp 1459 - 1459; DOI: 10.1021/jm00186a601 |
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Additions and Corrections - Quantitative Structure-Activity Relationships for N-[(N',N'-Disubstituted-amino)acetyl]arylamines for Local Anesthetic Activity and Acute Toxicity Françoise Heymans, Laurence Le Thérizien, Jean-Jacques Godfroid, and Pierre Bessin pp 1459 - 1459; DOI: 10.1021/jm00186a602 |
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Additions and Corrections - 10, 10-Difluoro-13-dehydroprostacyclin: A Chemically and Metabolically Stabilized Potent Prostacyclin. Josef Fried, D. K. Mitra, M. Nagarajan, and M. M .Mehrotra pp 1459 - 1459; DOI: 10.1021/jm00186a603 |
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Additions and Corrections - 2,4-Diamino-5-benzylpyrimidines and Analogues as Antibacterial Agents. 3. C-Benzylation of Aminopyridines with Phenolic Mannich Bases. Synthesis of 1- and 3-Deaza Analogues of Trimethoprom. Barbara S. Rauckman, and Barbara Roth pp 1459 - 1459; DOI: 10.1021/jm00186a604 |
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Additions and Corrections - Inhibition of Ribosomal Peptidyltransferase with 2'(3')-O-Acetyl-2''(3'')-O-glycyl-1,2-di(adenosin-N6-yl)ethane and 1,4-di(adenosin-N6-yl)butane. Effect of Alkyl Chain Length. Masayoshi Murata, Prakash Bhuta, James Owens, and Jiri Zemlicka pp 1459 - 1459; DOI: 10.1021/jm00186a605 |
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Additions and Corrections - Studies on Cardiovascular Agents. 6. Synthesis and Coronary Vasodilating and Antihypertensive Activities of 1,2,4-Triazolo[1,5-α]pyrimidines Fused to Heterocyclic Systems. Yasunobu Sasto, Yasuo Shimoji, Hiroshi Fujita, Hiroshi Nishino, Hiroshi Mizuno, Shinsaku Kobayashi, and Seihi Kumakura pp 1459 - 1459; DOI: 10.1021/jm00186a606 |
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Additions and Corrections - Annual Review of Neuroscience. Volume 3. L. G. Abood pp 1459 - 1459; DOI: 10.1021/jm00186a607 |